SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

Abstract The SUMO protease SENP6 maintains genomic stability, but mechanistic understanding of this process remains limited. We find that SENP6 deconjugates SUMO2/3 polymers on a group of DNA damage response proteins, including BRCA1-BARD1, 53BP1, BLM and ERCC1-XPF. SENP6 maintains these proteins in...

Full description

Bibliographic Details
Main Authors: Laura A. Claessens, Matty Verlaan-de Vries, Ilona J. de Graaf, Alfred C. O. Vertegaal
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41623-w

Internet

https://doi.org/10.1038/s41467-023-41623-w

Similar Items