Genome-Wide Meta-Analysis Identifies Variants in DSCAM and PDLIM3 That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib

Individual response to sunitinib in metastatic renal cell carcinoma (mRCC) patients is highly variable. Earlier, sunitinib outcome was related to single nucleotide polymorphisms (SNPs) in CYP3A5 and ABCB1. Our aim is to provide novel insights into biological mec...

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Bibliographic Details
Main Authors:	Meta H. M. Diekstra, Jesse J. Swen, Loes F. M. van der Zanden, Sita H. Vermeulen, Epie Boven, Ron H. J. Mathijssen, Koya Fukunaga, Taisei Mushiroda, Fumiya Hongo, Egbert Oosterwijk, Anne Cambon-Thomsen, Daniel Castellano, Achim Fritsch, Jesus Garcia Donas, Cristina Rodriguez-Antona, Rob Ruijtenbeek, Marius T. Radu, Tim Eisen, Kerstin Junker, Max Roessler, Ulrich Jaehde, Tsuneharu Miki, Stefan Böhringer, Michiaki Kubo, Lambertus A. L. M. Kiemeney, Henk-Jan Guchelaar
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Cancers
Subjects:	genome wide association study sunitinib pharmacogenetics metastatic renal cell carcinoma clear cell renal cell carcinoma single nucleotide polymorphism
Online Access:	https://www.mdpi.com/2072-6694/14/12/2838

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https://www.mdpi.com/2072-6694/14/12/2838

Genome-Wide Meta-Analysis Identifies Variants in <i>DSCAM</i> and <i>PDLIM3</i> That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib

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