Phosphosulindac (OXT-328) prevents and reverses chemotherapy induced peripheral neuropathy in mice

Phosphosulindac (OXT-328) prevents and reverses chemotherapy induced peripheral neuropathy in mice

BackgroundChemotherapy-induced peripheral neuropathy (CIPN), a side effect of chemotherapy, is particularly difficult to treat. We explored whether phosphosulindac (PS), a modified NSAID, could treat CIPN.MethodsCIPN was induced in male C57BL/6 J mice by paclitaxel, vincristine or oxaliplatin. Mecha...

Full description

Bibliographic Details
Main Authors: Aryah Basu, Jennifer Y. Yang, Vasiliki E. Tsirukis, Andrew Loiacono, Gina Koch, Ishan A. Khwaja, Mahila Krishnamurthy, Nicholas Fazio, Emily White, Aayushi Jha, Shrila Shah, Cameron Takmil, Deniz Bagdas, Aylin Demirer, Adam Master, Ernest Natke, Robert Honkanen, Liqun Huang, Basil Rigas
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Neuroscience
Subjects:
chemotherapy-induced peripheral neuropathies (CIPN)
phosphosulindac
neuroinflammation
paclitaxel
mechanical allodynia
prevention/treatment of CIPN
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1240372/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1240372/full

Similar Items