Gene dispersion is the key determinant of the read count bias in differential expression analysis of RNA-seq data
Abstract Background In differential expression analysis of RNA-sequencing (RNA-seq) read count data for two sample groups, it is known that highly expressed genes (or longer genes) are more likely to be differentially expressed which is called read count bias (or gene length bias). This bias had gre...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-05-01
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| Series: | BMC Genomics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12864-017-3809-0 |