Altered GnRH neuron and ovarian innervation characterize reproductive dysfunction linked to the Fragile X messenger ribonucleoprotein (Fmr1) gene mutation

Altered GnRH neuron and ovarian innervation characterize reproductive dysfunction linked to the Fragile X messenger ribonucleoprotein (Fmr1) gene mutation

IntroductionMutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene cause Fragile X Syndrome, the most common monogenic cause of intellectual disability. Mutations of FMR1 are also associated with reproductive disorders, such as early cessation of reproductive function in females. While...

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Bibliographic Details
Main Authors: Pedro A. Villa, Nancy M. Lainez, Carrie R. Jonak, Sarah C. Berlin, Iryna M. Ethell, Djurdjica Coss
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Endocrinology
Subjects:
Fragile X Syndrome
FMR1
GnRH
hypothalamus
FSH
ovary innervation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1129534/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1129534/full

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