Erdheim–Chester Disease Due to a Novel Internal Duplication of NRAS: Response to Targeted Therapy with Cobimetinib

Erdheim–Chester Disease Due to a Novel Internal Duplication of NRAS: Response to Targeted Therapy with Cobimetinib

Histiocytoses encompass a group of exceptionally rare disorders characterized by the abnormal infiltration of tissues by histocytes. Among these, Erdheim–Chester disease (ECD) stands out as a multisystem histiocytosis that typically affects bones and various other tissues. Historically, the treatmen...

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Bibliographic Details
Main Authors: José A. Riancho, José L. Hernández, Carmen González-Vela, Ana E. López-Sundh, Marcos A. González-Lopez, Francisco Gomez de la Fuente, Remedios Quirce, Eli L. Diamond
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
histiocytosis
Erdheim–Chester disease
cobimetinib
NRAS
targeted therapy
kinase inhibitors
Online Access:https://www.mdpi.com/1422-0067/24/20/15467

Internet

https://www.mdpi.com/1422-0067/24/20/15467

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