Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway

Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway

Cardiovascular complications are a well-documented limitation of conventional cancer chemotherapy. As a notable side effect of cisplatin, cardiotoxicity represents a major obstacle to the treatment of cancer. Recently, it has been reported that cyclic GMP-AMP synthase (cGAS) stimulator of interferon...

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Bibliographic Details
Main Authors: Lintao Wang, Suya Zhang, Jibo Han, Xiaoyan Nie, Yajun Qi, Yingying Han, Xiong Chen, Chaoyong He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
stimulator of interferon genes
cisplatin
tumor necrosis factor-α
activator protein 1
cardiotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.711238/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.711238/full

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