Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer

Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer

Abstract Background Endometrial cancer (EC) is a major gynecological cancer with increasing incidence. It comprises four molecular subtypes with differing etiology, prognoses, and responses to chemotherapy. In the future, clinical trials testing new single agents or combination therapies will be tar...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Vanessa F. Bonazzi, Olga Kondrashova, Deborah Smith, Katia Nones, Asmerom T. Sengal, Robert Ju, Leisl M. Packer, Lambros T. Koufariotis, Stephen H. Kazakoff, Aimee L. Davidson, Priya Ramarao-Milne, Vanessa Lakis, Felicity Newell, Rebecca Rogers, Claire Davies, James Nicklin, Andrea Garrett, Naven Chetty, Lewis Perrin, John V. Pearson, Ann-Marie Patch, Nicola Waddell, Pamela M. Pollock
Format: Artykuł
Język:English
Wydane: BMC 2022-01-01
Seria:Genome Medicine
Hasła przedmiotowe:
Endometrial cancer
Patient-derived xenografts
Genomic characterization
Mutational signatures
Genomic scarring
Tumor heterogeneity
Dostęp online:https://doi.org/10.1186/s13073-021-00990-z

Internet

https://doi.org/10.1186/s13073-021-00990-z

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