Smurf1 Suppression Enhances Temozolomide Chemosensitivity in Glioblastoma by Facilitating PTEN Nuclear Translocation

Smurf1 Suppression Enhances Temozolomide Chemosensitivity in Glioblastoma by Facilitating PTEN Nuclear Translocation

The tumor suppressor PTEN mainly inhibits the PI3K/Akt pathway in the cytoplasm and maintains DNA stability in the nucleus. The status of PTEN remains therapeutic effectiveness for chemoresistance of the DNA alkylating agent temozolomide (TMZ) in glioblastoma (GB). However, the underlying mechanisms...

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Bibliographic Details
Main Authors: Lei Dong, Yang Li, Liqun Liu, Xinyi Meng, Shengzhen Li, Da Han, Zhenyu Xiao, Qin Xia
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
TMZ
drug resistance
glioblastoma
smurf1
PTEN
Online Access:https://www.mdpi.com/2073-4409/11/20/3302

Internet

https://www.mdpi.com/2073-4409/11/20/3302

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