Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling

Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling

Abstract Background Angiogenesis and osteogenesis are closely interrelated. The interaction between endothelial and bone-forming cells, such as osteoblasts, is crucial for normal bone development and repair. Juxtacrine and paracrine mechanisms play key roles in cell differentiation towards the osteo...

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Main Authors: Perepletchikova Daria, Kuchur Polina, Basovich Liubov, Khvorova Irina, Lobov Arseniy, Azarkina Kseniia, Aksenov Nikolay, Bozhkova Svetlana, Karelkin Vitaliy, Malashicheva Anna
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
Endothelial cells
Osteoblasts
Osteogenic differentiation
Notch signaling
Co-culture
Online Access:https://doi.org/10.1186/s12964-025-02096-0

Internet

https://doi.org/10.1186/s12964-025-02096-0

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