Development of a Novel Live Attenuated Influenza A Virus Vaccine Encoding the IgA-Inducing Protein

Development of a Novel Live Attenuated Influenza A Virus Vaccine Encoding the IgA-Inducing Protein

Live attenuated influenza virus (LAIV) vaccines elicit a combination of systemic and mucosal immunity by mimicking a natural infection. To further enhance protective mucosal responses, we incorporated the gene encoding the IgA-inducing protein (IGIP) into the LAIV genomes of the cold-adapted A/Lenin...

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Bibliographic Details
Main Authors: C. Joaquín Cáceres, Stivalis Cardenas-Garcia, Aarti Jain, L. Claire Gay, Silvia Carnaccini, Brittany Seibert, Lucas M. Ferreri, Ginger Geiger, Algimantas Jasinskas, Rie Nakajima, Daniela S. Rajao, Irina Isakova-Sivak, Larisa Rudenko, Amy L. Vincent, D. Huw Davies, Daniel R. Perez
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Vaccines
Subjects:
LAIV
influenza
HA
IGIP
IgA
IgG
Online Access:https://www.mdpi.com/2076-393X/9/7/703

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https://www.mdpi.com/2076-393X/9/7/703

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