Reduced Fitness Costs of <italic toggle="yes">mcr-1.2</italic> Compared to Mutated <italic toggle="yes">pmrB</italic> in Isogenic Colistin-Resistant KPC-3-Producing <named-content content-type="genus-species">Klebsiella pneumoniae</named-content>

Reduced Fitness Costs of <italic toggle="yes">mcr-1.2</italic> Compared to Mutated <italic toggle="yes">pmrB</italic> in Isogenic Colistin-Resistant KPC-3-Producing <named-content content-type="genus-species">Klebsiella pneumoniae</named-content>

ABSTRACT In the present study, we provide the results of a detailed genomic analysis and the growth characteristics of a colistin-resistant KPC-3-producing Klebsiella pneumoniae sequence type 512 (ST512) isolate (the colR-KPC3-KP isolate) with a mutated pmrB and isogenic isolates of colR-KPC3-KP wit...

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Bibliographic Details
Main Authors: Cesira Giordano, Adrian Klak, Simona Barnini, Monika A. Chlebowicz, Mariacristina Menconi, John W. Rossen, Alexander W. Friedrich, Erik Bathoorn
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSphere
Subjects:
colistin
fitness cost
mcr-1.2
molecular epidemiology
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00551-19

Internet

https://journals.asm.org/doi/10.1128/mSphere.00551-19

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