In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer.
Non-conventional MHC class I MIC molecules interact not with the TCR, but with NKG2D, a C-type lectin activatory receptor present on most NK, gammadelta and CD8(+) alphabeta T cells. While this interaction is critical in triggering/calibrating the cytotoxic activity of these cells, the actual extent...
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
| Julkaistu: |
Public Library of Science (PLoS)
2007-01-01
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| Sarja: | PLoS ONE |
| Linkit: | http://europepmc.org/articles/PMC1885219?pdf=render |