Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition

Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition

Abstract Background Recurrence due to the development of radioresistance remains a major challenge in the clinical management of nasopharyngeal carcinoma. The objective of this study was to increase the sensitivity of nasopharyngeal carcinoma cells to ionizing radiation by enhancing oxidative stress...

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Bibliographic Details
Main Authors: Alvan Amos, Ning Jiang, Dan Zong, Jiajia Gu, Jiawei Zhou, Li Yin, Xia He, Yong Xu, Lirong Wu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Cancer
Subjects:
Ferroptosis
Nasopharyngeal carcinoma
Oxidative stress
SOD2
DHODH
Online Access:https://doi.org/10.1186/s12885-022-10465-y

Internet

https://doi.org/10.1186/s12885-022-10465-y

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