MiR-431 attenuates synaptic plasticity and memory deficits in APPswe/PS1dE9 mice

MiR-431 attenuates synaptic plasticity and memory deficits in APPswe/PS1dE9 mice

Synaptic plasticity impairment plays a critical role in the pathogenesis of Alzheimer’s disease (AD), and emerging evidence has shown that microRNAs (miRs) are alternative biomarkers and therapeutic targets for synaptic dysfunctions in AD. In this study, we found that the level of miR-431 was downre...

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Bibliographic Details
Main Authors: Jianwei Ge, Zhiwei Xue, Shu Shu, Linjie Yu, Ruomeng Qin, Wenyuan Tao, Pinyi Liu, Xiaohong Dong, Zhen Lan, Xinyu Bao, Lei Ye, Yun Xu, Xiaolei Zhu
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-06-01
Series:JCI Insight
Subjects:
Aging
Therapeutics
Online Access:https://doi.org/10.1172/jci.insight.166270

Internet

https://doi.org/10.1172/jci.insight.166270

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