Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome

Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome

Oxidative stress (OS) is one of the neuropathological mechanisms responsible for the deficits in cognition and neuronal function in Down syndrome (DS). The Ts65Dn (TS) mouse replicates multiple DS phenotypes including hippocampal-dependent learning and memory deficits and similar brain oxidative sta...

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Bibliographic Details
Main Authors: Alba Puente-Bedia, María T. Berciano, Carmen Martínez-Cué, Miguel Lafarga, Noemí Rueda
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antioxidants
Subjects:
Ts65Dn
hippocampus
down syndrome
granule cells
oxidative stress
DNA damage
Online Access:https://www.mdpi.com/2076-3921/11/12/2438

Internet

https://www.mdpi.com/2076-3921/11/12/2438

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