First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study

First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study

Abstract Background Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic anhydrase XII and injected into the re...

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Bibliographic Details
Main Authors: Wolfgang Roll, Michael Müther, Guido Böning, Astrid Delker, Nils Warneke, Franz-Josef Gildehaus, Michael Schäfers, Walter Stummer, Reinhard Zeidler, Hans-Jürgen Reulen, Lars Stegger
Format: Article
Language:English
Published: SpringerOpen 2023-09-01
Series:EJNMMI Research
Subjects:
Radioimmunotherapy
Carbonic anhydrase XII
Immunoglobulin Fab fragments
Glioblastoma
Lutetium-177
Online Access:https://doi.org/10.1186/s13550-023-01029-7

Internet

https://doi.org/10.1186/s13550-023-01029-7

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