Oral Immunization with F4 Fimbriae and CpG Formulated with Carboxymethyl Starch Enhances F4-Specific Mucosal Immune Response and Modulates Th1 and Th2 Cytokines in Weaned Pigs

Purpose. F4 fimbriae are a potential candidate for an oral subunit vaccine for prevention of post-weaning diarrhea in swine due to infection with F4-positive enterotoxigenic Escherichia coli. However, large quantities of F4 fimbriae are required to induce a specific antibody response. The aim of the...

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Bibliographic Details
Main Authors: Benjamin Delisle, Carmen Calinescu, Mircea Alexandru Mateescu, John Morris Fairbrother, Eric Nadeau
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/18159