Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b

Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b

Defense against Haemophilus influenzae type b (Hib) is dependent on antibodies and complement, which mediate both serum bactericidal activity (SBA) and opsonophagocytosis. Here we evaluated the influence of capsule-specific antibodies and complement inhibitors targeting the central component C3, the...

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Bibliographic Details
Main Authors: Lukas Muri, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Emma Ispasanie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
Haemophilus influenzae type b
serum bactericidal activity (SBA)
opsonophagocytosis
complement inhibitors
alternative pathway (AP)
vaccination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020580/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020580/full

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