Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice

Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice

Abstract Background Several phosphodiesterase 4 (PDE4) inhibitors have emerged as potential therapeutics for central nervous system (CNS) diseases. This study investigated the pharmacological effects of two selective PDE4 inhibitors, roflumilast and zatolmilast, against lipopolysaccharide-induced ne...

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Bibliographic Details
Main Authors: Dong Ho Kang, Sunjoo Ahn, Jung Woo Chae, Jin Sook Song
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Neuroscience
Subjects:
PDE4B
PDE4D
Neuroinflammation
Roflumilast
Zatolmilast
Brain dispostion
Online Access:https://doi.org/10.1186/s12868-023-00810-7

Internet

https://doi.org/10.1186/s12868-023-00810-7

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