Combination Therapy of Chloroquine and C2-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells

Combination Therapy of Chloroquine and C2-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells

Non-small cell lung cancer (NSCLC) is a type of malignant cancer, and 85% of metastatic NSCLC patients have a poor prognosis. C2-ceramide induces G2/M phase arrest and cytotoxicity in NSCLC cells. In this study, the autophagy-inducing effect of C2-ceramide was demonstrated, and cotreatment with the...

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Bibliographic Details
Main Authors: Han-Lin Chou, Yi-Hsiung Lin, Wangta Liu, Chang-Yi Wu, Ruei-Nian Li, Hurng-Wern Huang, Chi-Hsien Chou, Shean-Jaw Chiou, Chien-Chih Chiu
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
NSCLC
C2-ceramide
chloroquine
autophagy
combination treatment
Online Access:http://www.mdpi.com/2072-6694/11/3/370

Internet

http://www.mdpi.com/2072-6694/11/3/370

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