Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca<sup>2+</sup> Handling and Arrhythmogenesis

Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca<sup>2+</sup> Handling and Arrhythmogenesis

Phospholamban (PLN), a key modulator of Ca<sup>2+</sup>-homeostasis, inhibits sarcoplasmic reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human <i>PLN</i> mutation R14del has been identified in arrhythmogenic cardiomyopathy patients worldwide...

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Bibliographic Details
Main Authors: Elizabeth Vafiadaki, Kobra Haghighi, Demetrios A. Arvanitis, Evangelia G. Kranias, Despina Sanoudou
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
phospholamban
R14del mutant
cardiomyopathy
cardiac arrhythmias
Online Access:https://www.mdpi.com/1422-0067/23/13/6947

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https://www.mdpi.com/1422-0067/23/13/6947

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