Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca<sup>2+</sup> Handling and Arrhythmogenesis
Phospholamban (PLN), a key modulator of Ca<sup>2+</sup>-homeostasis, inhibits sarcoplasmic reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human <i>PLN</i> mutation R14del has been identified in arrhythmogenic cardiomyopathy patients worldwide...
Main Authors: | Elizabeth Vafiadaki, Kobra Haghighi, Demetrios A. Arvanitis, Evangelia G. Kranias, Despina Sanoudou |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/13/6947 |
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