LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).

Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3) and resides at the linkage peak for late-onset Alzheimer's disease (LOAD) risk and plasma amyloid β (Aβ) levels. In-vitro knock-down of LRRTM3 was pre...

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Bibliographic Details
Main Authors: Sarah Lincoln, Mariet Allen, Claire L Cox, Louise P Walker, Kimberly Malphrus, Yushi Qiu, Thuy Nguyen, Christopher Rowley, Naomi Kouri, Julia Crook, V Shane Pankratz, Samuel Younkin, Linda Younkin, Minerva Carrasquillo, Fanggeng Zou, Samer O Abdul-Hay, Wolfdieter Springer, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Zbigniew K Wszolek, Jada M Lewis, Dennis Dickson, Neill R Graff-Radford, Ronald C Petersen, Elizabeth Eckman, Steven G Younkin, Nilüfer Ertekin-Taner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3672107?pdf=render

Internet

http://europepmc.org/articles/PMC3672107?pdf=render

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