MRPA-independent mechanisms of antimony resistance in Leishmania infantum

Control of both human and canine leishmaniasis is based on a very short list of chemotherapeutic agents, headed by antimonial derivatives (Sb). The utility of these molecules is severely threatened by high rates of drug resistance. The ABC transporter MRPA is one of the few key Sb resistance protein...

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Bibliographic Details
Main Authors: Noélie Douanne, Victoria Wagner, Gaetan Roy, Philippe Leprohon, Marc Ouellette, Christopher Fernandez-Prada
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320720300051