Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells

Regulatory T cells (Tregs) prevent autoimmunity but limit antitumor immunity. The canonical NF-κB signaling pathway both activates immunity and promotes thymic Treg development. Here, we report that mature Tregs continue to require NF-κB signaling through IκB-kinase β (IKKβ) after thymic egress. Mic...

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Bibliographic Details
Main Authors: Christoph Heuser, Janine Gotot, Eveline Christina Piotrowski, Marie-Sophie Philipp, Christina Johanna Felicia Courrèges, Martin Sylvester Otte, Linlin Guo, Jonathan Leo Schmid-Burgk, Veit Hornung, Annkristin Heine, Percy Alexander Knolle, Natalio Garbi, Edgar Serfling, César Evaristo, Friedrich Thaiss, Christian Kurts
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
regulatory T cells
NF-κB pathway
tumor vaccination
checkpoint inhibition
cytotoxic T cells
cross-priming
apoptosis
tumor immunology
melanoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313876

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http://www.sciencedirect.com/science/article/pii/S2211124717313876

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