Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog—GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition

Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog—GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition

(1) Background: Aberrant activation of the hedgehog (HH)—GLI pathway in stem-like tumor-initiating cells (TIC) is a frequent oncogenic driver signal in various human malignancies. Remarkable efficacy of anti-HH therapeutics led to the approval of HH inhibitors targeting the key pathway effector smoo...

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Bibliographic Details
Main Authors: Elisabeth Peer, Sophie Karoline Aichberger, Filip Vilotic, Wolfgang Gruber, Thomas Parigger, Sandra Grund-Gröschke, Dominik Patrick Elmer, Florian Rathje, Andrea Ramspacher, Mirko Zaja, Susanne Michel, Svetlana Hamm, Fritz Aberger
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
Hedgehog—GLI signaling
Hedgehog pathway inhibitors
casein kinase 1D
smoothened drug resistance
tumor-initiating cells
cancer stem cells
Online Access:https://www.mdpi.com/2072-6694/13/16/4227

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https://www.mdpi.com/2072-6694/13/16/4227

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