Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration

Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration

Type 1 interferons (IFN) are an antiviral cytokine family, important in juvenile onset systemic lupus erythematosus (jSLE) which is more common in females, around puberty. We report that plasmacytoid dendritic cells (pDC) from healthy females produced more type 1 IFN after toll like receptor (TLR) 7...

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Bibliographic Details
Main Authors: Kate Webb, Hannah Peckham, Anna Radziszewska, Madhvi Menon, Paola Oliveri, Fraser Simpson, Claire T. Deakin, Sophie Lee, Coziana Ciurtin, Gary Butler, Lucy R. Wedderburn, Yiannis Ioannou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
interferon
TLR7
immunity
sex
puberty
SLE
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03167/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03167/full

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