Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth

Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth

In this study, the CAR-like multivalent aptamer nanoparticles (X-polymers) were assembled with the dimer of murine CD28 RNA aptamer (CD28Apt7), the tetramer of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) RNA aptamer (Del60), and a folic acid labeled ssDNA fragment in a stable nucleic acid t...

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Bibliographic Details
Main Authors: Chenjun Bai, Shanshan Gao, Sai Hu, Xuemei Liu, Hui Li, Jie Dong, Aixue Huang, Lingling Zhu, Pingkun Zhou, Shaohua Li, Ningsheng Shao
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
multivalent
aptamers
self-assemble
T cells
melanoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300231

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http://www.sciencedirect.com/science/article/pii/S2372770520300231

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