DEFLATE Compression Algorithm Corrects for Overestimation of Phylogenetic Diversity by Grantham Approach to Single-Nucleotide Polymorphism Classification

DEFLATE Compression Algorithm Corrects for Overestimation of Phylogenetic Diversity by Grantham Approach to Single-Nucleotide Polymorphism Classification

Improvements in speed and cost of genome sequencing are resulting in increasing numbers of novel non-synonymous single nucleotide polymorphisms (nsSNPs) in genes known to be associated with disease. The large number of nsSNPs makes laboratory-based classification infeasible and familial co-segregati...

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Bibliographic Details
Main Authors: Arran Schlosberg, Brian Y. H. Lam, Giles S. H. Yeo, Roderick J. Clifton-Bligh
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:International Journal of Molecular Sciences
Subjects:
DEFLATE
compression
Grantham
variation
sequence alignment
nsSNP
Online Access:http://www.mdpi.com/1422-0067/15/5/8491

Internet

http://www.mdpi.com/1422-0067/15/5/8491

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