<i>DAZL</i> Knockout Pigs as Recipients for Spermatogonial Stem Cell Transplantation

<i>DAZL</i> Knockout Pigs as Recipients for Spermatogonial Stem Cell Transplantation

Spermatogonial stem cell (SSC) transplantation into the testis of a germ cell (GC)-depleted surrogate allows transmission of donor genotype via donor-derived sperm produced by the recipient. Transplantation of gene-edited SSCs provides an approach to propagate gene-edited large animal models. DAZL i...

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Bibliographic Details
Main Authors: Nathalia L. M. Lara, Taylor Goldsmith, Paula Rodriguez-Villamil, Felipe Ongaratto, Staci Solin, Dennis Webster, Uyanga Ganbaatar, Shane Hodgson, Stanislas M. A. S. Corbière, Alla Bondareva, Daniel F. Carlson, Ina Dobrinski
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
spermatogonial stem cell transplantation
DAZL
DAZL knockout
genetically modified pigs
Online Access:https://www.mdpi.com/2073-4409/12/21/2582

Internet

https://www.mdpi.com/2073-4409/12/21/2582

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