Glycoprotein folding and quality-control mechanisms in protein-folding diseases

Biosynthesis of proteins – from translation to folding to export – encompasses a complex set of events that are exquisitely regulated and scrutinized to ensure the functional quality of the end products. Cells have evolved to capitalize on multiple post-translational modifications in addition to pri...

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Bibliographic Details
Main Authors: Sean P. Ferris, Vamsi K. Kodali, Randal J. Kaufman
Format: Article
Language:English
Published: The Company of Biologists 2014-03-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/7/3/331