Glycoprotein folding and quality-control mechanisms in protein-folding diseases
Biosynthesis of proteins – from translation to folding to export – encompasses a complex set of events that are exquisitely regulated and scrutinized to ensure the functional quality of the end products. Cells have evolved to capitalize on multiple post-translational modifications in addition to pri...
Main Authors: | Sean P. Ferris, Vamsi K. Kodali, Randal J. Kaufman |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2014-03-01
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Series: | Disease Models & Mechanisms |
Subjects: | |
Online Access: | http://dmm.biologists.org/content/7/3/331 |
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