TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis

TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis

Spondyloarthritis (SpA) comprises a number of inflammatory rheumatic diseases with overlapping clinical manifestations. Strong association with several HLA-I alleles and T cell infiltration into an inflamed joint suggest involvement of T cells in SpA pathogenesis. In this study, we performed high-th...

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Bibliographic Details
Main Authors: Ekaterina A. Komech, Anastasia D. Koltakova, Anna A. Barinova, Anastasia A. Minervina, Maria A. Salnikova, Evgeniya I. Shmidt, Tatiana V. Korotaeva, Elena Y. Loginova, Shandor F. Erdes, Ekaterina A. Bogdanova, Mikhail Shugay, Sergey Lukyanov, Yury B. Lebedev, Ivan V. Zvyagin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
TCR repertoire
spondyloarthritis
synovial fluid
ankylosing spondylitis
psoriatic arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.973243/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.973243/full

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