Smad3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat.

Smad3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat.

Carvedilol, a nonselective β-adrenoreceptor antagonist, protects against myocardial injury induced by acute myocardium infarction (AMI). The mechanisms underlying the anti-fibrotic effects of carvedilol are unknown. Recent studies have revealed the critical role of microRNAs (miRNAs) in a variety of...

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Main Authors: Jie-Ning Zhu, Ren Chen, Yong-Heng Fu, Qiu-Xiong Lin, Shuai Huang, Lin-Lin Guo, Meng-Zhen Zhang, Chun-Yu Deng, Xiao Zou, Shi-Long Zhong, Min Yang, Jian Zhuang, Xi-Yong Yu, Zhi-Xin Shan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086569/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086569/pdf/?tool=EBI

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