β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

Diabetes is caused by the inability of electrically coupled, functionally heterogeneous β-cells within the pancreatic islet to provide adequate insulin secretion. Functional networks have been used to represent synchronized oscillatory [Ca2+] dynamics and to study β-cell subpopulations, which play a...

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Bibliographic Details
Main Authors: Jennifer K Briggs, Anne Gresch, Isabella Marinelli, JaeAnn M Dwulet, David J Albers, Vira Kravets, Richard KP Benninger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-11-01
Series:eLife
Subjects:
islet
network theory
coordinated oscillations
β-cell oscillations
Online Access:https://elifesciences.org/articles/83147

Internet

https://elifesciences.org/articles/83147

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