A combined 2-D and 3-D QSAR modeling, molecular docking study, design, and pharmacokinetic profiling of some arylimidamide-azole hybrids as superior L. donovani inhibitors

A combined 2-D and 3-D QSAR modeling, molecular docking study, design, and pharmacokinetic profiling of some arylimidamide-azole hybrids as superior L. donovani inhibitors

Abstract Background Leishmaniasis is one of the neglected tropical diseases which is prevalent in the tropical regions of the world most especially in Africa. It is caused by the Leishmania species and transmitted to humans majorly through the bite of the female sandfly. This study was carried out i...

Full description

Bibliographic Details
Main Authors: Fabian Audu Ugbe, Gideon Adamu Shallangwa, Adamu Uzairu, Ibrahim Abdulkadir
Format: Article
Language:English
Published: SpringerOpen 2022-06-01
Series:Bulletin of the National Research Centre
Subjects:
Arylimidamide-azole
DFT
Leishmaniasis
Molecular docking
Pharmacokinetics
2-D QSAR
Online Access:https://doi.org/10.1186/s42269-022-00874-1

Internet

https://doi.org/10.1186/s42269-022-00874-1

Similar Items