Relationship between CYP3A5 Polymorphism and Tacrolimus Blood Concentration Changes in Allogeneic Hematopoietic Stem Cell Transplant Recipients during Continuous Infusion

Relationship between CYP3A5 Polymorphism and Tacrolimus Blood Concentration Changes in Allogeneic Hematopoietic Stem Cell Transplant Recipients during Continuous Infusion

A polymorphism in the gene encoding the metabolic enzyme cytochrome P450 family 3 subfamily A member 5 (CYP3A5) is a particularly influential factor in the use of tacrolimus in Japanese patients. Those who are homozygotic for the <i>*3</i> mutation lack CYP3A5 activity, which results in...

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Bibliographic Details
Main Authors: Naoki Yoshikawa, Hidemi Takeshima, Masaaki Sekine, Keiichi Akizuki, Tomonori Hidaka, Kazuya Shimoda, Ryuji Ikeda
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
cytochrome P450 family 3 subfamily a member 5
tacrolimus
gene polymorphism
therapeutic drug monitoring
hematopoietic stem cell transplantation
Online Access:https://www.mdpi.com/1424-8247/14/4/353

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https://www.mdpi.com/1424-8247/14/4/353

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