Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

Abstract Background MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in various cancers, including brain tumors...

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Bibliographic Details
Main Authors: Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi, Don W. Coulter
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Cancer
Subjects:
Medulloblastoma
PRMT5
MYC protein
PRMT5 inhibitor
Online Access:http://link.springer.com/article/10.1186/s12885-019-6291-z

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http://link.springer.com/article/10.1186/s12885-019-6291-z

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