DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION
A sensitive method for quantification of pinoline and its metabolite in human plasma using solid phase extraction and high performance liquid chromatography with mass-spectrometry was developed. Analytical range was 250-1500 pg/ml both for pinoline and for 6-hydroxy-1,2,3,4-tetrahydro-β-carboline. T...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Sprog: | Russian |
| Udgivet: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
|
| Serier: | Разработка и регистрация лекарственных средств |
| Fag: | |
| Online adgang: | https://www.pharmjournal.ru/jour/article/view/240 |