DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION

DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION

A sensitive method for quantification of pinoline and its metabolite in human plasma using solid phase extraction and high performance liquid chromatography with mass-spectrometry was developed. Analytical range was 250-1500 pg/ml both for pinoline and for 6-hydroxy-1,2,3,4-tetrahydro-β-carboline. T...

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Bibliographic Details
Main Authors: R. K. Abdrashitov, A. E. Petukhov, V. V. Smirnov
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01
Series:Разработка и регистрация лекарственных средств
Subjects:
cyp2d6
lc-ms/ms
пинолин
6-гидрокси-1,2,3,4-тетрагидро-β-карболин
Online Access:https://www.pharmjournal.ru/jour/article/view/240

Internet

https://www.pharmjournal.ru/jour/article/view/240

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