DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION
A sensitive method for quantification of pinoline and its metabolite in human plasma using solid phase extraction and high performance liquid chromatography with mass-spectrometry was developed. Analytical range was 250-1500 pg/ml both for pinoline and for 6-hydroxy-1,2,3,4-tetrahydro-β-carboline. T...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/240 |
| _version_ | 1797875030705569792 |
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| author | R. K. Abdrashitov A. E. Petukhov V. V. Smirnov |
| author_facet | R. K. Abdrashitov A. E. Petukhov V. V. Smirnov |
| author_sort | R. K. Abdrashitov |
| collection | DOAJ |
| description | A sensitive method for quantification of pinoline and its metabolite in human plasma using solid phase extraction and high performance liquid chromatography with mass-spectrometry was developed. Analytical range was 250-1500 pg/ml both for pinoline and for 6-hydroxy-1,2,3,4-tetrahydro-β-carboline. The developed method may be used to determine the current status of CYP2D6 activity. |
| first_indexed | 2024-04-10T01:41:16Z |
| format | Article |
| id | doaj.art-4ba17a4156d648f9bd42e4a925047470 |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:41:16Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-4ba17a4156d648f9bd42e4a9250474702023-03-13T09:13:57ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0101190194240DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATIONR. K. Abdrashitov0A. E. Petukhov1V. V. Smirnov2Первый МГМУ им. И.М. СеченоваФГБУ «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства РоссииФГБУ «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства РоссииA sensitive method for quantification of pinoline and its metabolite in human plasma using solid phase extraction and high performance liquid chromatography with mass-spectrometry was developed. Analytical range was 250-1500 pg/ml both for pinoline and for 6-hydroxy-1,2,3,4-tetrahydro-β-carboline. The developed method may be used to determine the current status of CYP2D6 activity.https://www.pharmjournal.ru/jour/article/view/240cyp2d6lc-ms/msпинолин6-гидрокси-1,2,3,4-тетрагидро-β-карболин |
| spellingShingle | R. K. Abdrashitov A. E. Petukhov V. V. Smirnov DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION Разработка и регистрация лекарственных средств cyp2d6 lc-ms/ms пинолин 6-гидрокси-1,2,3,4-тетрагидро-β-карболин |
| title | DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION |
| title_full | DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION |
| title_fullStr | DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION |
| title_full_unstemmed | DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION |
| title_short | DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION |
| title_sort | development and validation of bioanalytical method for quantification of pinoline and its metabolite 6 oh 1 2 3 4 tetrahydrocarboline for the purpose of cypd26 activity determination |
| topic | cyp2d6 lc-ms/ms пинолин 6-гидрокси-1,2,3,4-тетрагидро-β-карболин |
| url | https://www.pharmjournal.ru/jour/article/view/240 |
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