Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis

Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis

During pregnancy, estrogen (E2) stimulates uterine artery blood flow (UBF) by enhancing nitric oxide (NO)-dependent vasodilation. Cystathionine γ-lyase (CSE) promotes vascular NO signaling by producing hydrogen sulfide (H2S) and by maintaining the ratio of reduced-to-oxidized intracellular glutathio...

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Bibliographic Details
Main Authors: Rachael Bok, Damian D. Guerra, Ramón A. Lorca, Sara A. Wennersten, Peter S. Harris, Abhishek K. Rauniyar, Sally P. Stabler, Kenneth N. MacLean, James R. Roede, Laura D. Brown, K. Joseph Hurt
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Redox Biology
Subjects:
Cystathionine γ-lyase (CSE)
Estrogen
Glutathione (GSH)
Nitric oxide (NO)
Oxidative stress
Uterine blood flow
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720310326

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http://www.sciencedirect.com/science/article/pii/S2213231720310326

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