Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation

Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation

Abstract Background Postoperative cognitive dysfunction (POCD) is a very common complication that might increase the morbidity and mortality of elderly patients after surgery. However, the mechanism of POCD remains largely unknown. The NAD-dependent deacetylase protein Sirtuin 3 (SIRT3) is located i...

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Bibliographic Details
Main Authors: Qiang Liu, Yi-Man Sun, Hui Huang, Chen Chen, Jie Wan, Lin-Hui Ma, Yin-Ying Sun, Hui-Hui Miao, Yu-Qing Wu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
SIRT3
Postoperative cognitive dysfunction
Mitochondrial oxidative stress
Neuroinflammation
Microglia
Synaptic plasticity
Online Access:https://doi.org/10.1186/s12974-021-02089-z

Internet

https://doi.org/10.1186/s12974-021-02089-z

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