Intranasal Administration of a TRAIL Neutralizing Monoclonal Antibody Adsorbed in PLGA Nanoparticles and NLC Nanosystems: An In Vivo Study on a Mouse Model of Alzheimer’s Disease

Intranasal Administration of a TRAIL Neutralizing Monoclonal Antibody Adsorbed in PLGA Nanoparticles and NLC Nanosystems: An In Vivo Study on a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder that progressively compromises cognitive functions. Tumor necrosis factor (TNF)-Related Apoptosis Inducing Ligand (TRAIL), a proinflammatory cytokine belonging to the TNF superfamily, appears to be a key player in the inflammatory/immune orche...

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Bibliographic Details
Main Authors: Teresa Musumeci, Giulia Di Benedetto, Claudia Carbone, Angela Bonaccorso, Giovanni Amato, Maria Josè Lo Faro, Chiara Burgaletto, Giovanni Puglisi, Renato Bernardini, Giuseppina Cantarella
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
nanomedicine
polymers
lipids
monoclonal antibody
mice
nose-to-brain delivery
Online Access:https://www.mdpi.com/2227-9059/10/5/985

Internet

https://www.mdpi.com/2227-9059/10/5/985

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