A dual role for pleiotrophin in modulating inflammation and myelination in the presence of chondroitin sulfate proteoglycans after nervous system injury

A dual role for pleiotrophin in modulating inflammation and myelination in the presence of chondroitin sulfate proteoglycans after nervous system injury

Chondroitin sulfate proteoglycans (CSPGs), key components of the extracellular matrix and the glial scar that forms around central nervous system (CNS) injuries, are recognized for hindering neuronal regeneration. We previously demonstrated the potential of pleiotrophin (PTN) to induce neurite outgr...

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Bibliographic Details
Main Authors: Somnath J. Gupta, Matthew A. Churchward, Kathryn G. Todd, Ian R. Winship
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
stroke
CSPGs
OPCs
oligodendrocytes
microglia
PTN
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1549433/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2025.1549433/full

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