Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation.

Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation.

The P23H mutation in the rhodopsin gene causes rhodopsin misfolding, altered trafficking and formation of insoluble aggregates leading to photoreceptor degeneration and autosomal dominant retinitis pigmentosa (RP). There are no effective therapies to treat this condition. Compounds that enhance diss...

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Bibliographic Details
Main Authors: Vidyullatha Vasireddy, Venkata R M Chavali, Victory T Joseph, Rajendra Kadam, Jonathan H Lin, Jeffrey A Jamison, Uday B Kompella, Geereddy Bhanuprakash Reddy, Radha Ayyagari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3126808?pdf=render

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http://europepmc.org/articles/PMC3126808?pdf=render

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