Large-scale in vitro microdosimetry via live cell microscopy imaging: implications for radiosensitivity and RBE evaluations in alpha-emitter radiopharmaceutical therapy

Large-scale in vitro microdosimetry via live cell microscopy imaging: implications for radiosensitivity and RBE evaluations in alpha-emitter radiopharmaceutical therapy

Abstract Background Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising outcomes in metastatic disease. However, the short range of the alpha particles necessitates dosimetry on a near-cellular spatial scale. Current knowledge on cellular dosimetry is primarily based on in vitro exp...

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Bibliographic Details
Main Authors: Remco Bastiaannet, Ioanna Liatsou, Robert F Hobbs, George Sgouros
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Translational Medicine
Subjects:
Alpha emitter
Radiopharmaceutical therapy
Microdosimetry
Single-cell dosimetry
Radiosensitivity
Radiobiology
Online Access:https://doi.org/10.1186/s12967-023-03991-1

Internet

https://doi.org/10.1186/s12967-023-03991-1

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