Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2

Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2

Failed or altered gliogenesis is a major characteristic of diffuse white matter injury in survivors of premature birth. The developmentally regulated long noncoding RNA (lncRNA) H19 inhibits S-adenosylhomocysteine hydrolase (SAHH) and contributes to methylation of diverse cellular components, such a...

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Bibliographic Details
Main Authors: Marialuigia Spinelli, Celiné Boucard, Sara Ornaghi, Andreina Schoeberlein, Keller Irene, Daniel Coman, Fahmeed Hyder, Longbo Zhang, Valérie Haesler, Angelique Bordey, Eytan Barnea, Michael Paidas, Daniel Surbek, Martin Mueller
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-10-01
Series:JCI Insight
Subjects:
Neuroscience
Therapeutics
Online Access:https://doi.org/10.1172/jci.insight.132335

Internet

https://doi.org/10.1172/jci.insight.132335

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