Therapeutic Targeting of DNA Replication Stress in Cancer

This article reviews the currently used therapeutic strategies to target DNA replication stress for cancer treatment in the clinic, highlighting their effectiveness and limitations due to toxicity and drug resistance. Cancer cells experience enhanced spontaneous DNA damage due to compromised DNA rep...

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Bibliographic Details
Main Authors: Long Gu, Robert J. Hickey, Linda H. Malkas
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/14/7/1346