Pruning and thresholding approach for methylation risk scores in multi-ancestry populations

Pruning and thresholding approach for methylation risk scores in multi-ancestry populations

Recent efforts have focused on developing methylation risk scores (MRS), a weighted sum of the individual’s DNA methylation (DNAm) values of pre-selected CpG sites. Most of the current MRS approaches that utilize Epigenome-wide association studies (EWAS) summary statistics only include genome-wide s...

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Bibliographic Details
Main Authors: Junyu Chen, Evan Gatev, Todd Everson, Karen N. Conneely, Nastassja Koen, Michael P. Epstein, Michael S. Kobor, Heather J. Zar, Dan J. Stein, Anke Hüls
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Epigenetics
Subjects:
epigenetic scores
polygenic dna methylation
clumping and thresholding
admixed population
Online Access:http://dx.doi.org/10.1080/15592294.2023.2187172

Internet

http://dx.doi.org/10.1080/15592294.2023.2187172

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